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Jurnal yang sering digunakan untuk penelitian kedokteran:
• Cancer
• Nutrition
& Cancer
• Journal
of Clinical Oncology
• Journal
of the National Cancer Institute
• Cancer
Research
• Integrative
Cancer Therapies
• American
Journal of Clinical Nutrition
• Alternative
Medicine Review
• International
Journal of Cancer
• Clinical
Pearls
• Anticancer
Research
• Townsend
Letter for Doctors & Their Patients
WEB RESOURCES
• www.oncanp.org
• www.aicr.org
• www.lifeovercancer.com
• www.cancerfacts.com
• www.nci.nih.gov
• www.cancernet.nci.nih.gov/clinpdq
• www.cancer.org American Cancer Society 1-800-ACS-2345
• www.cdc.gov.org/cancer
• www.bccancer.bc.ca
• www.y-me.org
• www.asco.org
• www.Medscape.com - oncology database
• www.inspirehealth.ca
• www.denvernaturopathic.com
• www.camresearch.net
• www.ncbi.nlm.nih.gov/PubMed/
• www.oncologystat.com
• www.epec.net
• www.lifeovercancer.com
Topic penelitian yang sedang menarik yang dapat anda gunakan
untuk diteliti:
An Alternative Medicine Definitive Guide to Cancer, Diamond,
Cowden & Goldberg, Future Medicine Publishing, 1997.
Genetic Program Linking Cancer to Hemostasis Identified,
Boccaccio, et al., Nature 2005; 434: 396-400.
Metastasis: A Therapeutic Target for Cancer, Steeg &
Theodorescu, Nat. Clin. Pract. Oncol. 2008; 5 (4): 206-219.
Effect of Gamma-Linolenic Acid on the Transcritional
Activity of the Her-2/neu (erbB-2) Oncogene, Menendez, Vellon, Colomer &
Lupu, J. Natl. Cancer Inst. 2005; 97 (2): 1611-1615.
Herb-Drug Interactions in Oncology: Focus on Mechanisms of
Induction, Meijerman, Bejnen and Schellens, Oncologist 2006; 11: 742-752.
Energy-modulating Vitamins – A New Combinatorial Therapy
Prevents Cancer Cachexia in Rat Mammary Carcinoma, Perumai, Shanthi &
Sachdanandam, Br. J. Nutr. 2005; 93(6): 901-909.
P13 Kinase /Akt Pathway as a Therapeutic Target in Multiple
Myeloma, Harvey & Lonial, Future Oncol. 2007; 3(6): 639-647.
Starvation-dependent Differential Stress Resistance Protects
Normal but Not Cancer Cells Against High-dose Chemotherapy, Raffaghello, Lee,
Sadfie, et al., Proc Natl Acad Sci USA
2008; 105 (24): 8215-8220.
Targeting Energy Metabolism in Brain Cancer Through Calorie
Restriction and the Ketogenic Diet,
Seyfried, Kiebish, Marsh & Mukherjee, J. Can. Res. Ther. 2009; 5: 7-15. PMID: 20009300
Bringing Evidence to Complementary and Alternative Medicine
in Children with Cancer: Focus on Nutrition-related Therapies, Kelly, Pediatr. Blood Cancer 2008; 50 (2 Suppl):
490-493; discussion 498.
The Use of a Whey Protein Concentrate in the Treatment of
Patients with Metastatic Carcinoma: A Phase I-II Clinical Study, Kennedy,
Anticancer Res. 1995; 15 (6B): 2643-2649.
Adherence to Mediterranean Diet and Health Status:
Meta-analysis, Sofe, Cesari, Abbate, et al., BMJ 2008; 337: a1344.
Early Hormonal Data from a Multicentre Phase II Trial Using
Transdermal Oestrogen Patches as a First-line Hormonal Therapy in Patients with
Locally Advanced or Metastatic Prostate Cancer, Langley, Godsland, Kynastn, et
al., BJU Int. 2008; 102 (4): 442-445.
Dietary Alpha-, Beta-, Gamma- and Delta-Tocopherols in Lung
Cancer Risk, Mahabir, Schendel, Dong, et al., Int. J. Cancer 2008; 123:
1173-1180.
Allergic Pulmonary Inflammation Promotes the Recruitment of
Circulating Tumor Cells to the Lung, Taranova, Maldonado, Vachon, et al.,
Cancer Res. 2008; 68 (20): 8582-8589.
Interaction of
Warfarin with Drugs, Natural Substances, and Foods, Greenblatt & von
Moltke, J. Clin. Pharmacol. 2005; 45 (2): 127-132.
Intensive Lifestyle Changes May Affect the Progression of
Prostate Cancer, Ornish, Weidner, Fair, et al., J Urol. 2005; 174 (3):
1065-1069.
High Casein-Lactalbumin Diet Accelerates Blood Coagulation
in Rats, Chan, Lou & Hargrove, J. Nutr. 1993; 123 (6): 1010-1016.
Therapeutic Applications of Whey Protein, Marshall, Altern.
Med. Rev. 2004; 9 (2): 136-156.
Dairy Products, Calcium, and Vitamin D and Risk of Prostate
Cancer, Chan & Giovannucci, Epidemiol. Rev. 2001; 23 (1): 87-92.
Lycopene and Apo-12- Lycopenal Reduce Cell Proliferation and
Alter Cell Cycle Progression in Human Prostate Cancer Cells, Ford, Elsen,
Zuniga, et al., Nutr. Cancer 2011; 63 (2): 256–263.
Serum Phospholipid Fatty Acids and Prostate Cancer Risk:
Results From the Prostate Cancer Prevention Trial, Brasky, Till, White,et al., Am. J. Epidemiol.
2011; doi: 10.1093/aje/kwr027
Testosterone Therapy in Men With Untreated Prostate Cancer,
Morgentaler, Lipshultz, Bennett, et al., J. Urol. 2011; 185 (4): 1256-1260.
Radical Prostatectomy Versus Watchful Waiting in Early
Prostate Cancer, Bill-Axelson, Holmberg,
Ruutu, et al., N. Engl. J. Med. 2011; 364: 1708-1717,
1770-1772.
A High Ratio of Dietary n-6/n-3 Polyunsaturated Fatty Acids
is Associated with Increased Risk of Prostate Cancer, Williams, Whitley, Hoyod,
et al., Nutr. Res. 31 2011; 31: 1–8.
Dairy Products and Breast Cancer: the IGF-I, Estrogen, and
bGH Hypothesis, Outwater, Nicholson & Barnard, Med. Hypotheses 1997; 48
(6): 453-461.
Prospective Study of Grapefruit Intake and Risk of Breast
Cancer in Postmenopausal Women: the Multi-ethnic Cohort Study, Monroe, Murphy,
Kolonel & Pike, Br. J. Cancer 2007; 697 (3): 440-445.
Does Grapefruit Juice Increase the Bioavailability of Orally
Administered Sex Steroids? Fingerová, Oborná, Petrová, et al., Ceska Gynekol.
2003; 68 (2): 117-121.
Gamma-linolenic Acid Therapy of Human Glioma- A Review of in
vitro, in vivo, and Clinical Studies, Das,
Med. Sci. Monit. 2007; 13 (7): RA119-131.
Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid, Kapoor & Huang, Curr. Pharm. Biotechnol.
2006; 7(6): 531-534.
Non-linear Dynamics for Clinicians: Chaos Theory, Fractals,
and Complexity at the Bedside, Goldberger, Lancet 1996; 347: 1312–1314.
Megadose Vitamins in Bladder Cancer: A Double-blind Clinical
Trial, Lamm, Riggs, Shriver et al., J.
Urol. 1994; 151 (1): 21-26
Health Implications of Mediterranean Diets in Light of
Contemporary Knowledge: Meat, Wine,
Fats, and Oils, Kushi, Lenart & Willett, Am. J. Clin. Nutr. 1995; 61
(6Suppl): 1416S-1427S.
Adherence to the Mediterranean Diet Attenuates Inflammation
and Coagulation Process in Healthy Adults: The ATTICA Study, Chrysohoou,
Panagiotakos, Pitsavos, et al., J. Am. Coll. Cardiol. 2004; 44 (1): 152-158.
Fibrinogen: A Novel Predictor of Responsiveness in
Metastatic Melanoma Patients Treated with Bio-chemotherapy: IMI (Italian
Melanoma Inter-group) Trial, Guida, Ravaioli, Sileni, et al., J. Transl. Med.
2003; 1 (1): 13.
Analysis of Botanicals and Dietary Supplements for
Antioxidant Capacity: A Review, Prior, Cao, Prior & Cao,
J. AOAC Int. 2000; 83 (4): 950-956.
Selenium for Preventing Cancer, Dennert, Zwahlen, Brinkman,
et al., Cochrane Database of Systematic Reviews 2011, 5: CD005195. DOI: 10.1002/14651858.CD005195.pub2
Seronea repens (Permixon, Saw Palmetto)Inhibits the
5-alpha-reductase Activity of Human Prostate Cancer Cell Lines Without
Interfering with PSA Expression, Habib, Ross, Ho, et al., Int. J. Cancer 2005;
114 (2); 190-194.
Paraneoplastic Syndromes: An Approach to Diagnosis and
Treatment, Pelosof & Gerber, Mayo Clin. Proc. 2010; 85 (9): 838-854.
The Tumor Lysis Syndrome, Howard, Jones, & Pui, N. Engl.
J. Med. 2011; 364: 1844-1854.
Impact of Stress and Mast Cells on Brain Metastases,
Theoharides, Rozniecki , Sahagian, et al.,
J. Neuroimmunol. 2008; 205 (1-2): 1-7.
Pancreatic Proteolytic Enzyme Therapy Compared With
Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer, Chabot,
Tsai, Fine, et al., J. Clin. Oncol. 2009 Aug 17. [Epub ahead of print] PMID
19687327.
Berberine and Berberine-containing Plants as Antineoplastic
Agents, Tang, Feng, Wang, et al., J. Ethnopharmacol. 2009; 128: 5-17.
Inhibitory Effects of Berberine on the Activation and Cell
Cycle Progression of Human Peripheral Lymphocytes, Cell. Mol. Immunol. Xu, Liu
& He, 2005; 2 (4): 295-300.
Association Between Coffee Drinking and K-ras Mutations in
Exocrine Pancreatic Cancer, Porta, Malats, Guarner, et al., J Epidem. Comm.
Health 1999; 53: 702–709
Increased Rates of Chromosome Breakage in BRCA1 Carriers are
Normalized by Oral Selenium Supplementation, Kowalska, Narod, Huzarski, et al.,
Cancer Epidem. Biomark. & Prev. 2005; 14 (5): 1302-1306.
ProstaCaid Induces G2/M Cell Cycle Arrest and Apoptosis in
Human and Mouse Androgen–Dependent and – Independent Prostate Cancer Cells, Yan
& Katz, Integr. Cancer Ther. 2010; 9: 186-196.
A Tissue Biomarker Panel Predicting Systemic Progression
after PSA Recurrence Post-Definitive Prostate Cancer Therapy, Nakagawa,
Kollmeyer, Morlan, et.al., PLoS ONE 2008; 3 (5): e2318. Epub 2008 May 28.
Perioperative
Arginine-Supplemented Nutrition in Malnourished Patients with Head and
Neck Cancer Improves Long-term Survival,
Buijs, van Leeuwen, et al, Amer.
J. Clin. Nutr. 2010; [Epub ahead of print] September 29, 2010,
doi:10.3945/ajcn.2010.29532
Acetyl-L-Carnitine Monograph, Alt. Med. Rev. 2010; 15 (1):
76-83.
Dietary Vitamin K Intake in Relation to Cancer Incidence and
Mortality: Results from the Heidelberg Cohort of the European Prospective
Investigation into Cancer and Nutrition (EPIC-Heidelberg), Nimptsch, Rohrmann,
Kaaks & Linseisen, Am. J. Clin. Nutr. 2010; 91 (5): 1348-1358. Comment in:
Am. J. Clin. Nutr. 2010; 92 (6): 1533-1534; author reply 1534-1535.
Choline. A Nutrient that is Involved in the Regulation of
Cell Proliferation, Cell Death, and Cell Transformation, Zeisel, Adv. Exp. Med. Biol. 1996; 399: 131-141.
A Low Carbohydrate, High Protein Diet Slows Tumor Growth and
Prevents Cancer Initiation, Ho, Leung, Hsu, et al. Cancer Res. 2011; 71:
4484-4493.
Forgiveness Can Improve Immune Function, Owen, Soc. Behav.
Med. 32nd Annual Meeting and Scientific Sessions: Abstract 4010. Presented
April 30, 2011.
Selenium for Preventing Cancer, Dennert, Zwahlen, Brinkman,
et al., Cochrane Database of Systematic Reviews 2011, 5: CD005195. DOI:
10.1002/14651858.CD005195.pub2
GINGER
Ginger for Chemotherapy-related Nausea in Cancer Patients: A
URCC CCOP Randomized, Double-blind, Placebo-controlled Clinical Trial of 644
Cancer Patients, Ryan, Heckler, Dakhil et al., J. Clin. Oncol. 2009: 27: 15s, (suppl; abstr 9511 - 2009 ASCO Annual Meeting).
Phase II Trial of Encapsulated Ginger as a Treatment for
Chemotherapy-induced Nausea and Vomiting, Zick, Ruffin, Lee et al., Support
Care Cancer 2009; 17 (5): 563-572.
A Phase II/III Randomized, Placebo-Controlled, Double-Blind
Clinical Trial of Ginger (Zingiber officinale) for Nausea Caused by
Chemotherapy for Cancer: A Currently Accruing URCC CCOP Cancer Control
Study, Hickok, Roscoe, Morrow &
Ryan, Support. Cancer Ther. 2007; 4 (4):
247-250.
Protein and Ginger for the Treatment of Chemotherapy-induced
Delayed Nausea, Levine, Gillis, Koch et al., J. Altern. Complement. Med. 2008;
14 (5): 545-551.
Antiemetic Effect of Ginger in Gynecologic Oncology Patients
Receiving Cisplatin. Manusirivithaya, Sripramote, Tangjitgamol et al., Int. J.
Gynecol. Cancer 2004; 14 (6): 1063-1069.
Anti-Emetic Effect of Ginger Powder Versus Placebo as an
Add-on Therapy in Children and Young Adults Receiving High Emetogenic
Chemotherapy, Pillai, Sharma, Gupta & Bakhshi, Pediatr. Blood Cancer 2011;
56 (2): 234-238.
GRAPESEED EXTRACT
& RESVERATROL
Oligomeric Proanthocyanidin Complexes: History, Structure
& Phytopharmaceutical Applications, A. M. Fine. Alt. Med Rev. 2000; Vol. 5, No. 2:
144-151.
Cellular Protection with Proanthocyanidins Derived from
Grape Seeds, Bagchi, Bagchi & Stohs,
et al, Ann. N. Y. Acad. Sci. 2002; 957:
260-270.
Oligomeric Proanthocyanidins ( OPCs) – Monograph, Alt. Med. Rev. 2003; Vol. 8, No.4: 442-450.
Chemoprevention of Colorectal Cancer by Grapeseed
Proanthocyanidin is Accompanied by a Decrease in Proliferation and Increase in
Apoptosis, Nomoto, Iigo, Hamada, et al.
Nutr. & Cancer. 2004; Vol. 49, No. 1: 81-89.
Alcohol and Polyphenolic Grape Extract Inhibit Platelet
Adhesion in Flowing Blood, de Lange, Scholman, Kraaijenhagen, et al., Eur. J.
Clin. Invest. 2004; 4 (12): 818-824.
Red Wine and Red Wine Polyphenolic Compounds But Not Alcohol
Inhibit ADP-induced Platelet Aggregation, de Lange, van Golden, Scholman, et
al., Eur. J. Intern. Med. 2003; 14 (6): 361-366.
Grape Seed and Skin Extracts Inhibit Platelet Function and
Release of Reactive Oxygen Intermediates, Vitseva, Varghese, Chakrabarti, et
al., J. Cardiovasc. Pharmacol. 2005; 46 (4): 445-451.
Proanthocyanidin from Grape Seeds Enhances Anti-tumor Effect
of Doxorubicin Both in vitro & in vivo, Zhang, Bai, Wu, et al, Pharmazie,
2005; 60: 533-538.
Grape Seed Proanthocyanidin Extract Induced
Mitochondria-associated Apoptosis in Human Acute Myeloid Leukaemia 14.3D10
Cells, Hong & Qin, Chin. Med. J.
2006; 119 (5): 417-421.
Grapeseed Extract Induces Apoptotic Death of Human Prostate
Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of
Mitochondrial membrane Potential and Cytochrome C Release, Agarwal, Singh &
Agarwal, Carcinogenesis 2002; 23 (11): 1869-1876.
Suppression of Estrogen Biosynthesis by Procyanidin Dimers
in Red Wine and Grape Seeds, Eng, Ye, Williams, et al., Cancer Res. 2003; 63
(23): 8516-8522.
Grapeseed Extract is an Aromatase Inhibitor and a Suppressor
of Aromatase Expression, Kijima, Phung,
Hur, et al., Cancer Res. 2006; 66 (11): 5960-5967.
Grapeseed Extract Inhibits Advanced Human Prostate Cancer
Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding
Protein 3, Singh, Tyagi, Dhanalakshmi, et al., Int. J. Cancer 2004; 108 (5):
733-740.
Grape Seed Extract Induces Anoikis and Caspase-mediated
Apoptosis in Human Prostate Carcinoma LNCaP Cells: Possible Role of Ataxia
Telangiectasis Mutated-p53 Activation, Kaur, Agarwal & Agarwal, Mol. Cancer
Ther. 2006; 5 (5): 1265-1274.
Grape Seed Proanthocyanidin Extract Induced
Mitochondria-associated Apoptosis in Human Acute Myeloid Leukaemia 14.3D10
cells, Hu & Qin, Chin. Med. J. 2006; 119 (5): 417-421.
Proanthocyanidins from Grape Seeds Inhibit Expression of
Matrix Metalloproteinases in Human Prostate Carcinoma Cells, Which is
Associated with the Inhibition of Activation of MAPK and NF kappa B, Vayalil,
Carcinogenesis 2004; 25 (6): 987-985.
Grape Seed Extract Inhibits Advanced Human Prostate Tumor
Growth and Angiogenesis and Upregulates Insulin-like Growth Factor Binding
Protein-3, Singh, Tyagi, Dhanalakshmi,
et al., Int. J. Cancer 2004; 108 (5): 733-740.
Grape Seed Extract Induces Apoptotic Death of Human Prostate
Carcinoma DU145 Cells Via Caspases Activation Accompanied by Dissipation of
Mitochondrial Membrane Potential and Cytochrome C Release, Agarwal, Singh &
Agarwal, Carcinogenesis 2002; 23 (11): 1869-1876.
Inhibition of NF-kappaB Pathway in Grape Seed
Extract-induced Apoptotic Death of Human Prostate Carcinoma DU145 Cells,
Dhanalakshmi, Agarwal & Agarwal, Int. J. Oncol. 2003; 23 (3): 721-727.
Grape Seed Extract Inhibits EGF-induced and Constituitively
Active Mitogenic Signallng but Activated JNK in Human Prostate Carcinoma DU145
Cells: Possible Role in Antiproliferation and Apoptosis, Tyagi, Agarwal &
Agarwal, Oncogene 2003; 22 (9): 1302-1316.
Matrix Metalloproteinases in Cancer Metastasis: Molecular
Targets for Prostate Cancer Prevention by Green Tea Polyphenols and Grape Seed
Proanthocyanidins, Katiyar, Endocr. Metabol. Immune Disord. Drug Targets, 2006;
6 (1): 17-24.
Anti-cancer Activity of Grape and Grape Skin Extracts Alone
and Combined with Green Tea Infusions, Morré & Morré, Cancer Lett. 2006;
238 (2): 202-209.
Grape Seed Extract Inhibits EGF-induced and Constitutively
Active Mitogenic Signaling But Activates JNK in Human Prostate Carcinoma DU145
Cells: Possible Role in Anti-proliferation and Apoptosis, Tyagi, Agarwal &
Agarwal, Oncogene 2003; 22 (9): 1302-1316.
Grape Seed Extract Inhibits in vitro and in vivo Growth of
Human Colorectal Carcinoma Cells, Kaur, Singh, Gu, et al., Clin. Cancer Res.
2006; 12 (20 Pt 1): 6194-6202.
Proanthocyanidin from Grape Seeds Inactivates the
PI3-kinase/PKB Pathway and Induces Apoptosis in a Colon Cancer Cell Line,
Engelbrecht, Mattheyse, Ellis, et al., Cancer Lett. 2007; 258 (1): 144-153.
Anti-angiogenic Efficacy of Grape Seed Extract in
Endothelial Cells, Agarwal, Singh, Dhanalakshmi & Agarwal, Oncol. Rep.
2004; 11 (3): 681-685.
Experimental Model for Treating Pulmonary Metastatic
Melanoma Using Grape-seed Extract, Red wine and Ethanol, Martínez Conesa,
Vicente Ortega, et al., Clin. Transl. Oncol. 2005; 7 (3): 115-121.
Grapeseed Extract Inhibits Angiogenesis via Suppression of
the Vascular Endothelial Growth Factor Receptor Signaling Pathway, Wen, Lu,
Zhang & Chen, Cancer Prev. Res. 2008; 1 (7): 554-561
Grapeseed Extract Inhibits VEGF Expression via Reducing
HIF-1 alpha Protein Expression, Lu, Zhang, Chen & Wen, Carcinogenesis 2009;
30 (4): 636-644.
Free Radicals and Grape Seed Proanthocyanidin Extract:
Importance in Human Health and Disease Prevention, Bagchi, Bagchi, Stohs, et
al., Toxicol. 2000; 148 (2-3): 187-197.
Chemoprevention of Colorectal Cancer by Grape Seed
Proanthocyanidin is Accompanied by a Decrease in Proliferation and Increase in
Apoptosis, Nomoto, Hiroshi, Iigo, et al., Nutr. & Cancer 2004; 49 (1):
81-89.
Synergistic Anti-cancer Effects of Grapeseed Extract and
Conventional Cytotoxic Agent Doxorubicin Against Human Breast Carcinoma Cells,
Sharma, Tyagi, Singh, et al., Breast Cancer Res. Treat. 2004; 85 (1): 1-12.
Chemopreventative Effects of Grape Seed Proanthocyanidin
Extract on Chang Liver Cells, Joshi, Kuszynski, Bagchi & Bagchi, Toxicol.
2000; 155: 83-90.
Gallic Acid, an Active Constituent of Grapeseed Extract,
Exhibits Anti-proliferative, Por-apoptotic and Anti-tumorigenic Effects Against
Prostate Carcinoma Xenograft Growth in Nude Mice, Kaur, Velmurugan,
Rajamanickam, et al., Pharm. Res. 2009; June 20 [Epub ahead of print] PMID: 19543955.
Molecular Mechanisms Behind the Chemopreventive Effects of
Anthocyanidins, Hou, Fujii, Terahara
&Yoshimoto, Biomed. Biotechnol.
2004; 2004 (5): 321-325.
Signal Transduction Pathways: Targets for Chemoprevention of
Skin Cancer, Bode, Lancet Oncol. 2000; 1: 181-188.
Dermal Wound Healing Properties of Redox-active Grape Seed
Proanthocyanidins, Khanna, Venojarvi, Roy, et al., Free Rad. Biol. Med. 2002;
33: 1089.
The Cytotoxic Effects of a Novel Grape Seed Proanthocyanidin
Extrct on Cultured Human Cancer Cells, Joshi, Ye, Liu, et al., Sci. Proc. 89th
Ann. Meet. Amer. Assoc. Cancer Res. 1998, Vol. 39.
Anti-thrombotic Effect of Proanthocyanidin, a Purified
Ingredient of Grape Seed, Sano, Oda, Yamashita, et al., Thromb. Res. 2005; 115:
115-121.
Induction of Apoptosis in Human Leukemia Cells by Grape Seed
Extract Occurs Via Activation of c-Jun NH2-Terminal Kinase, Gao, Budhraja,
Cheng , et al., Clin. Cancer Res. 2009; 15 (1): 140-149.
Effect of Concord Grape Juice on Chemotherapy-induced Nausea
and Vomiting: Results of a Pilot Study, Ingersoll, Wasilewski, Haller, et al.,
Oncol. Nurs. Forum 2010; 37 (2): 213-221.
Synergic Effect of Grape Seed Extract with Amphotericin B
against Disseminated Candidiasis Due to Candida albicans, Han,
Phytomedicine, 2007; 14:733–738.
http://dx.doi.org/10.1016/j.phymed.2007.08.004
Antibacterial and Antioxidant Activities of Grape (Vitis
vinifera) Seed Extracts, Jayaprakasha, Selvi, & Sakariah, Food Res. Intern.
2003; 36:117–122.
Relation Between Intake of Flavonoids and Risk for Coronary
Heart Disease in Male Health Professionals, Rimm, Katan, Ascherio, et al.,
Ann.Intern. Med. 1996; 125: 384–389.
Antiulcer Activity of Grape Seed Extract and Procyanidins,
Saito, Hosoyama, Ariga, et al., J. Agri. Food Chem. 1998; 46: 1460–1464.
Grape Seed Extract
Inhibits Advanced Human Prostate Tumor Growth and Angiogenesis and Upregulates
Insulin-like Growth Factor Binding Protein-3, Singh, Tyagi, Dhanalakshmi,
Agarwal, & Agarwal, C. Int. J. Cancer
2004; 108: 733–740.
Grapeseed Proanthocyanidin
Extract Induced Mitochondria-Associated Apoptosis in Human Acute Myeloid
Leukemia 14.3D10 Cells, Hu & Qin, Chin. Med. J. (Engl.) 2006; 119 (5):
417-421.
Pycnogenol as an Adjunct in the Management of Childhood
Asthma, Lau, Riesen, Truong, et al., J. Asthma 2004; 41 (8): 825-832.
Role of Resveratrol in Prevention and Therapy of Cancer:
Preclinical and Clinical Studies, Aggarwal, Bhardwaj, Aggarwal, et al.,
Anticancer Res. 2004; 24 (5A): 2783-2840.
Resveratrol-induced Apoptosis in Human Breast Cancer Cells
is Mediated Primarily Through the Caspase-3-dependent Pathway, Alkhalaf,
El-Mowafy, Renno , et al., Arch. Med. Res. 2008; 39 (2): 162-168.
Resveratrol Inhibits Proliferation, Induces Apoptosis, and
Overcomes Chemo-resistance Through Down-regulation of STAT3 and Nuclear
factor-kappaB-regulated Anti-apoptotic and Cell Survival Gene Products in Human
Multiple Myeloma Cells, Bhardwaj, Sethi, Vadhan-Raj, et al., Blood 2007; 109
(6): 2293-2302.
Resveratrol Induces the Suppression of Tumor-derived
CD4+CD25+ Regulatory T Cells, Yang, Paik,
Cho, et al., Int. Immunopharmacol. 2008; 8 (4): 542-547.
Resveratrol Induces Apoptosis and Differentiation in Acute
Pro-myelocytic Leukemia (NB4) Cells, Cao, Wang, Liu, et al., J. Asian Nat.
Prod. Res. 2005; 7 (4): 633-641.
Resveratrol: A Candidate Nutritional Substance for Prostate
Cancer Prevention, Stewart, Artime & O'Brian, J. Nutr. 2003; 133 (7 Suppl):
2440S-2443S.
Resveratrol Inhibits Aggregation of Platelets from High-risk
Cardiac Patients with Aspirin Resistance, Stef, Csiszar, Lerea, et al., J.
Cardiovasc. Pharmacol. 2006; 48 (2): 1-5.
Anti-angiogenic Activity of Resveratrol, a Natural Compound
from Medicinal Plants, Cao, Fu, Wang, et al., J. Asian Nat. Prod. Res. 2005; 7
(3): 205-224.
Resveratrol Acts as an Estrogen Receptor (ER) Agonist in
Breast Cancer Cells Stably Transfected with ER alpha, Levenson, Gehm, Pearce,
et al., Int. J. Cancer 2003; 104: 587-597.
The Cancer Preventative Agent Resveratrol is Converted to
the Anti-cancer Agent Piceattanol by the Cytochrome P450 Enzyme CYP1B1, Potter,
Patterson, Wanogho, et al., Br. J. Cancer 2002; 86: 774-778.
Involvement of p21WAF1/Cip1, pRB, Bax and NF-kappaB in
Induction of Growth Arrest and Apoptosis by Resveratrol in Human Lung Carcinoma
A549 cells, Kim, Lee, Choi, et al., Int. J. Oncol. 2003; 23 (4):
1143-1149.
Cancer Chemopreventive Activity of Resveratrol, Bhat &
Pezzuto, Ann. N. Y. Acad. Sci. 2002; 957: 210–229.
Resveratrol and N-AcetylCysteine Block the Cancer-Initiating
Step in MCF-10F Cells, Zahid, Saeed, Beseler, et al, Free Radic. Biol. 2010;
Epub Oct 7.
Med.<http://www.ncbi.nlm.nih.gov/pubmed/20934508?dopt=Abstract>
N-Acetyl-Cysteine, Reactive Oxygen Species and Beyond, Sun,
Cancer Biol. Ther. 2010; 9 (2): 109–110.
Mechanisms of Resveratrol-Induced Platelet Apoptosis, Lin, Hsiao,
Shih, et al., Cardiovasc. Res. 2009; 83 (3): 575-585.
Multiple Molecular Targets of Resveratrol: Anti-Carcinogenic
Mechanisms, Athar, Back, Kopelovich, et al., Arch. Biochem. Biophys. 2009; 486
(2): 95–102.
GREEN TEA EGCG
Green Tea Monograph, McKenna, Hughes & Jones, Alt. Ther.
May 2000; Vol. 6, No. 3: 61-84.
Green Tea Extract and (-)-Epigallocatechin-3-gallate, the
Major Tea Catechin, Exert Oxidant but Lack Antioxidant Activites, Elbling,
Weiss, Teufelhofer, et al., FASEB J. 2005; 19 (7): 807-809.
Prospective Cohort Study of Green Tea Consumption and
Colorectal Cancer Risk in Women, Yang, Shu, Li. Et al., Cancer Epidemiol.
Biomarkers Prev. 2007; 16 (6): 1219-1223.
Green Tea (Camellia sinensis) Extract Does Not Alter Cytochrome
P450 3A4 or 2D6 Activity in Healthy Volunteers, Donovan, Chavin &
Devane Drug. Metab. Dispos. 2004; 32:
906-908.
Efficacies of Tea Components on Doxorubicin-induced
Anti-tumor Activity and Reversal of Multi-drug
Resistance, Sadzuka, Sugiyama & Sonobe, Toxicol. Letters 2000; 114:
155-162.
Green Tea Inhibits VEGF Induction in Human Breast Cancer
Cells, Sartippour, Shao, Heber, et al, J. Nutr. 2002; 132: 2307-2311.
The Effects of Green Tea Consumption on Incidence of Breast
Cancer and Recurrence of Breast Cancer: A Systematic Review and Meta-analysis,
Seely, Mills, Wu P, et al., Integr.
Cancer Ther. 2005; 4 (2): 144-155.
Green Tea Catechins Inhibit VEGF-induced Angiogenesis in
vitro Through Suppression of VE-Cadherin Phosphorylation & Inactivation of
Akt Molecule, Tang, Nguyen &
Meydani, Int. J. Cancer 2003; 106: 871-878.
Epigallocatechin-3-gallate Inhibits Epidermal Growth Factor
Receptor Signalling Pathway. Evidence for Direct Inhibition of ERK1/2 and AKT
Kinases, Sah, Balasubramanian, Eckert & Rorke, J. Biol. Chem. 2004; 279
(13): 12755 – 12762.
Green Tea Appears to Protect Against Breast Cancer, Wu, Int.
J. Cancer 2003; 106: 574-579.
Green Tea Component Destroys Leukemia Cells, Kay, Blood
Mar.2, 2004 On-line edition.
Green Tea Catechins Containing a Galloyl Group in the 3'
Position Inhibit Tissue Factor-Induced Thrombin Generation, Stampfuss, Schror
& Weber, Thromb. Haemost. 2005; 93 (6): 1200-1201.
Green Tea Epigallocatechin-3-gallate Inhibits Platelet
Signalling Pathways Triggered by Both Proteolytic and Non-proteolytic Agonists,
Deana, Turetta, Donella-Deana, et al., Thromb Haemost. 2003; 89 (5): 866-874.
Tea Polyphenols, Their Biological Effects and Potential
Molecular Targets, Chen, Milacic, Chen, et al., Histol. Histopathol. 2008; 23
(4): 487-496.
Antioxidant Activity of Tea Polyphenols in vivo: Evidence
form Animal Studies, Frei & Higdon, J. Nutr. 2003; 133 (10): 3275S-3284S.
Clinical Effects of Oral Green Tea Extracts in Four Patients
with Low Grade B-cell Malignancies, Shanafelt, Lee, Call, et al., Leuk. Res.
2006; 30: 707-712.
Green Tea Polyphenols and Cancer Chemoprevention: Multiple
Mechanisms and Endpoints for Phase II Trials,
Moyers & Kumar, Nutr.
Rev. 2004; Vol. 62 No. 5: 204-211.
Pigments in Green Tea Leaves (Camellia sinensis) Suppress
Transformation of the Aryl Hydrocarbon Receptor Induced by Dioxin, Fukada,
Sakane, Yabushita, et al., J. Agric. Food Chem. 2004; 52 (9): 2499-2506.
Clinical Effects of Oral Green Tea Extracts in Four Patients
with Low Grade B-cell Malignancies, Shanafelt, Lee, Call, et al., Leuk. Res.
2006; 30 (6): 707-712.
Anti-oxidants from Green Tea and Pomegranate for
Chemoprevention of Prostate Cancer, Adhami and Mukhtar, Biotechnol. 2007; 37
(1): 52-57.
Inhibition of Aromatase Activity by Green Tea Extract
Catechins and Their Endocrinological Effects of Oral Administration in Rats,
Satoh, Sakamoto, Ogata, et al., Food Chem. Toxicol. 2002; 40 (7): 925-933.
Structure-Activity Relationships for Inhibition of Human
5-alpha-reductases by Polyphenols, Hiipkka, Zhang, Dai, et al., Biochem.
Pharmacol. 2002; 63 (6): 1165-1176.
Selective Inhibition of Steroid 5-alpha-reductase Isozymes
by Tea Epicatechin-3-gallate and Epigallocatechin-3-gallate, Liao &
Hipakka, Biochem. Biophys. Res. Commun.
1995; 214 (3): 833-838.
The Antifolate Activity of Tea Catechins, Navarro-peran,
Cabezas-Herrera, Garcia-Canovas, et al., Cancer Res. 2005; 65 (6): 2059-2064.
Effects of Aqueous Green Tea Extract on Activities of DNA
Turn-over Enzymes n Cancerous and Non-cancerous Human Gastric and Colon
Tissues, Ergruder, Namusui, Sozener, et al., Altern. Ther. Health Med. 2008; 14 (3): 30-33.
Interactions Affecting the Bioavailability of Dietary
Polyphenols in vivo, Scholz & Williamson, Int. J. Vitam. Nutr. Res. 2007;
77 (3): 224-235.
Green Tea Extracts for the Prevention of Metachronous
Colorectal Adenomas: A Pilot Study, Shimizu, Fukutomi, et al., Cancer
Epidemiol. Biomarkers Prev. 2008; 17 (11): 3020-3025.
Essential Role of Caspases in
Epigallocatechin-3-gallate-mediated Inhibition of Nuclear Factor kappa B and
Induction of Apoptosis, Gupta, et al., Oncogene 2004; 23 (14): 2507-2522.
Epigallocatechin-3-gallate is a Potent Natural Inhibitor of
Fatty Acid Synthase in Intact Cells and Selectively Induces Apoptosis in
Prostate Cancer Cells, Brusselmans, De Schrijver, Heyns, et al., Int. J. Cancer
2003; 106 (6): 856-862.
Prostate Carcinoma and Green Tea: PSA-triggered Basement
Membrane Degradation and MMP-2 Activation are Inhibited by (-)
Epigallocatechin-3-gallate, Pezzato, Sartor, Dell’Aica, et al., Int. J. Cancer
2004; 112 (5): 787-792.
EGCG Inhibits Activation of HER3 and Expression of
Cyclooxygenase-2 in Human Colon Cancer Cells, Shimizu, Deguchi , Joe, et al.,
J. Exp. Ther. Oncol. 2005; 5 (1): 69-78.
Epigallocatechin-3-gallate Inhibits Activation of HER-2/neu
and Downstream Signaling Pathways in Human Head and Neck and Breast Carcinoma
Cells, Masuda, Suzui, Lim & Weinstein, Clin. Cancer Res. 2003; 9 (9):
3486-3491.
Role of p53 and NF-kappaB in
Epigallocatechin-3-gallate-induced Apoptosis of LNCaP Cells, Hastak, Gupta,
Ahmad, et al., Oncogene 2003; 22 (31): 4851-4859.
Green Tea Constituent (-)-Epigallocatechin-3-gallate
Inhibits Hep G2 Cell Proliferation and Induces Apoptosis Through p53-dependent
and Fas-mediated Pathways, Kuo & Lin, J. Biomed. Sci. 2003;10 (2): 219-227.
Combined Effect of Green Tea and Ganoderma lucidum on
Invasive Behaviour of Breast Cancer Cells, Thyagarajan, Zhu & Sliva, Int.
J. Oncol. 2007; 30 (4): 963-969.
The Tea Polyphenol, (-)-Epigallocatechin Gallate Effects on
Growth, Apoptosis, and Telomerase Activity in Cervical Cell Lines, Yokoyama,
Noguchi, Nakao, et al., Gynecol. Oncol. 2004; 92 (1): 197-204.
EGCG Down-regulates Telomerase in Human Breast Carcinoma
MCF-7 Cells, Leading to Suppression of Cell Viability and Induction of
Apoptosis, Mittal, Pate, Wylie, et al., Int. J. Oncol. 2004; 24 (3): 703-710.
Matrix Metalloproteinases in Cancer Metastasis: Molecular
Targets for Prostate Cancer Prevention by Green Tea Polyphenols and Grape Seed
Proanthocyanidins, Katiyar, Endocr. Metabol. Immune Disord. Drug Targets, 2006;
6 (1): 17-24.
Anti-cancer Activity of Grape and Grape Skin Extracts Alone
and Combined with Green Tea Infusions, Morré & Morré, Cancer Lett. 2006;
238 (2): 202-209.
Green Tea Polyphenol Causes Differential Oxidative
Environments in Tumor versus Normal Epithelial Cells,Yamamoto, Hsu, Lewis, et
al., J. Pharmacol. Exp. Ther. 2003; 307 (1): 230-236.\
EGCG Inhibits Growth, Invasion, Angiogenesis and Metastasis
of Pancreatic Cancer, Shankar, Ganapathy, Hingorani & Srivastava, Front.
Biosci. 2008; 13: 440-452.
(-)-Epigallocatechin Gallate Inhibits Membrane-type 1 Matrix
Metalloproteinase, MT1-MMP, and Tumor Angiogenesis, Yamakawa, Asai, Uchida, et
al., Cancer Lett. 2004; 210 (1): 47-55.
Dietary Intakes of Mushrooms and Green Tea Combine to Reduce
the Risk of Breast Cancer in Chinese Women, Zhng, Huang, Xie & Holman, Int.
J. Cancer 2009; 1246: 1404-1408.
Phase II Randomized, Placebo-Controlled Trial of Green Tea
Extract in Patients with High-Risk Oral Premalignant Lesions, Tsao, Liu,
Martin, et al. Cancer Prev Res 2009; 2
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Natural Compounds with Proteasome Inhibitory Activity for
Cancer Prevention and Treatment, Yang, Landis-Piwowar, Chen, et al., Curr.
Protein Pept. Sci. 2008; 9 (3): 227-239.
Phase II Trial of Daily, Oral Green Tea Extract in Patients
with Asymptomatic, Rai Stage 0-II Chronic Lymphocytic Leukemia (CLL), Shanafelt, Call, Zent, et al., J. Clin.
Oncol. 2010; 28 (Suppl.): S7. Abstract 6522 ASCO 2010.
Green Tea Catechin
Controls Apoptosis in Colon Cancer Cells by Attenuation of H2O2-Stimulated
Cox-2 Expression via the AMPK Signaling Pathway at Low–Dose H2O2, Park, Lee,
Hwang, et al., Ann. N. Y. Acad. Sci. 2009;1171: 538-544.
Antithrombotic Activities of Green Tea Catechins and (-)-Epigallocatechin
Gallate, Kang, Lim, Yuk, et al., Thromb. Res. 1999; 96 (3): 229-237.
INDOLE-3-CARBINOL
Indole-3-Carbinol – Monograph, Alt. Med. Rev. 2005; Vol. 10
No. 4: 337-342.
Molecular Targets and Anticancer Potential of
Indole-3-Carbinol and Its Derivatives, Aggarwal & Ichikawa, Cell Cycle
2005; 4 (9): 1201-1215.
Changes in Levels of Urinary Estrogen Metabolite After Oral
Indole-3-Carbinol Treatment in Humans, Michnovicz, Adlercreutz & Bradlow,
J. Natl. Cancer Inst. 1997; 89 (10): 718-723.
Indole-3-Carbinol and Tamoxifen Cooperate to Arrest the Cell
Cycle of MCF-7 Human Breast Cancer Cells, Cover, Hsieh, Cram, et al., Cancer
Res. 1999; 59 (6):1244-1251.
Indole-3-Carbinol and Prostate Cancer, Sarkar, J. Nutr. 2004; 134 (12 Suppl): 3493S-3498S.
Indole-3-Carbinol as a Chemopreventive and Anti-cancer
Agent, Weng, Tsai, Kulp & Chen, Cancer Lett. 2008; 262 (2): 153-163.
Multiple Molecular Targets of Indole-3-Carbinol, a
Chemopreventative Anti-Estrogen in Breast Cancer, Ashtok, Chen, Garikapaty, et.
al., Eur. J. Cancer Prev. 2002; Suppl.
2: 86-93.
Placebo-controlled Trial of Indole-3-Carbinol in the
Treatment of CIN, Bell, Crowley-Nowick, Bradlow, et al., Gynecol. Oncol., 2000
Aug.; 78(2): 123-129.
Indole-3-Carbinol and 3’-3’-Diindolylmethane Antiproliferative
Signaling Pathways Control Cell-cycle Gene Transcription in Human Breast Cancer
Cells by Regulating Promoter-Sp1 Transcription Factor Interactions, Firestone
& Bjeldanes, J. Nutr. 2003; 133: 2448S-2455S.
Indole-3-carbinol Activates the ATM Signaling Pathway
Independent of DNA Damage to Stabilize p53 and Induce G1 Arrest of Human
Mammary Epithelial Cells. Brew,
Aronchik, Sheen, et al., Int. J. Cancer 2006 Feb 15; 118(4): 857-868.
BRCA1 and BRCA2 as Molecular Targets for Phytochemicals
Indole-3-carbinol and Genistein in Breast and Prostate Cancer Cells. Fan,
Meng, Auborn, et al., Br. J.
Cancer 2006 Feb 13; 94(3): 407-426.
Gene Expression Profiling Revealed Survivin as a Target of
3,3'-Diindolylmethane-Induced Cell Growth Inhibition and Apoptosis in Breast
Cancer Cells. Rahman, Li, Wang, et al., Cancer Res. 2006 ; 66 (9):
4952-4960.
Indole-3-Carbinol
(I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer
Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and
Subcellular Localization of the CDK2 Protein Complex. Garcia, Brar, Nguyen, et al., J.
Biol. Chem. 2005; 280, (10): 8756-8764.
Synthetic Dimer of Indole-3-Carbinol: Second Generation Diet
Derived Anti-Cancer Agent in Hormone Sensitive Prostate Cancer. Garikapaty, Ashok, Tadi, et al., Prostate 2006 Apr 1; 66(5): 453-462.
Indole-3-Carbinol (I3C) Induces Apoptosis in Tumorigenic but
Not in Non-tumorigenic Breast Epithelial Cells, Rahman, Aranha, & Sarkar,
Nutr. Cancer 2003; 45 (1): 101-112.
Translocation of Bax to Mitochondria Induces Apoptotic Cell
Death in Indole-3-Carbinol (I3C) Treated Breast Cancer Cells, Rahman, Aranha,
Glazyrin, et al, Oncogene 2000; 19 (50): 5764-5771.
Indole-3-Carbinol Enhances Ultraviolet-B-induced Apoptosis
by Sensitizing Human Melanoma Cells, Kim, Jeong, Moon, et al., Cell. Mol. Life
Sci. 2006; 63 (22): 2661-2668.
3,3’-Diindolylmethane is a Novel Mitochondrial H(+)-ATP
Synthase Inhibitor That Can Induce p21(Cip1/Waf1) Expression by Induction of
Oxidative Stress in Human Breast Cancer Cells, Gong, Sohn, Xue, et al., Cancer
Res. 2006; 66 (9): 4880-4887.
Apoptosis-inducing Effect of Erlotinib is Potentiated by
3,3’-Diindolylmethane in vitro and in vivo Using an Orthoptic Model of
Pancreatic Cancer, Ali, Banerjee, Ahmad,
et al., Mol. Cancer Ther. 2008; 7 (6): 1708-1719.
Indole-3-Carbinol and Prostate Cancer, Sarkhar & Li, J.
Nutr. 2004; 134 (12Suppl.): 3493S-3498S.
Indole-3-Carbinol Inhibition of Androgen Receptor Expression
and Down-regulation of Androgen Responsiveness in Human Prostate Cancer Cells,
Hsu, Zhang, Dev, et al., Carcinogenesis 2005;
Indole-3-Carbinol (I3C) Induced Cell Growth Inhibition, G1
Cell Cycle Arrest and Apoptosis in Prostate Cancer Cells, Chinni, Li, Upadhyay,
et al., Oncogene 2001;
Akt Inactivation is a Key Event in Indole-3-Carbinol-Induced
Apoptosis in PC-3 Cells, Chinni & Sarkhar, Clin. Cancer Res. 2002; 8 (4):
1228-1236.
Anti-carcinogenic and Anti-metastatic Properties of
Indole-3-Carbinol in Prostate Cancer, Garikpaty, et al., Oncol. Rep. 2005; 13 (1): 89-93.
Indole-3-carbinol Induces a G1 Cell Cycle Arrest and
Inhibits Prostate-specific Antigen Production in Human LNCaP Prostate Carcinoma
Cells, Zhang, Hsu, Kinseth, et al., Cancer 2003; 98 (11): 2511-2520.
Selective Growth Regulatory and Pro-apoptotic Effects of DIM
is Mediated by AKT and NF-kappaB Pathways in Prostate Cancer Cells, Li, Chinni
& Sarkhar, Front. Biosci. 2005; 10: 236-243.
Indole-3-Carbinol Prevents PTEN Loss in Cervical Cancer in
vivo, Qi, Anderson, Chen, et al., Mol. Med. 2005; 11 (1-12): 59-63.
BRCA1 and BRCA2 as Molecular Targets for Phytochemicals
Indole-3-Carbinol and Genistein in Breast and Prostate Cancer Cells, Fan, Meng,
Auborn, et al., Br. J. Cancer 2006; 94 (3): 407-426.
Molecular Targets and Anticancer Potential of
Indole-3-Carbinol and its Derivatives. Aggarwal & Ichikawa, Cell Cycle
2005; 4 (9): 1201-1215.
Intake of Cruciferous Vegetables Modifies Bladder Cancer
Survival, Tang, Zirpoli, Guru, et al., Cancer Epidemiol. Biomarkers Prev. 2010;
19 (7): 1806-1811.
A Novel Mechanism of Indole-3-Carbinol Effects on Breast
Carcinogenesis Involves Induction of Cdc25A Degradation, Wu, Feng, Jin, et al.,
Cancer Prev. Res. 2010; 3 (7): 818-828.
Indole-3-carbinol (I3C) Induces Apoptosis in Tumorigenic But
Not in Nontumorigenic Breast Epithelial Cells, Rahman, Aranha & Sarkar,
Nutr. Cancer 2003; 45 (1): 101-112.
